Cancer-causing Viruses May Use MicroRNAs to Alter Tumor
In cancer cells, metabolic pathways tend to be rewired to enable rapid proliferation and tumor growth. One such change is known as the Warburg effect—an alteration in the glucose breakdown process that provides energy for the cell. Previous research has suggested that cancer cells displaying the Warburg effect can also induce a similar “reverse Warburg” effect in adjacent cells.
To investigate the mechanism underlying the reverse Warburg effect, researchers turned to cells infected with Kaposi’s sarcoma-associated herpesvirus (KSHV). They found that KSHV can deliver small molecules of genetic material (microRNAs) to nearby non-infected cells in order to reprogram their metabolism, facilitating enhanced growth of the infected cells. This finding, published in PLOS Pathogens, suggests a possible mechanism by which tumors regulate their microenvironment.
General Patient Transfer Patterns Very Similar to Those Focused on Hospital-Acquired Infections
A new study shows that the networks formed by patterns of patient transfers between hospitals in France are very similar among three patient populations: those diagnosed with hospital-acquired infections (HAIs), those with suspected HAIs, and the general patient population. The research, published in PLOS Computational Biology, could help inform efforts to reduce the spread of HAIs.
Citation: Yogev O, Henderson S, Hayes MJ, Marelli SS, Ofir-Birin Y, Regev-Rudzki N, et al. (2017) Herpesviruses shape tumour microenvironment through exosomal transfer of viral microRNAs. PLoS Pathog 13(8): e1006524.
Citation: Nekkab N, Astagneau P, Temime L, Crépey P (2017) Spread of hospital-acquired infections: A comparison of healthcare networks. PLoS Comput Biol 13(8):e1005666.
Image Credit: George Washington University Emergency Medical Response Group (EMeRG) by Lee Cannon via Flickr.